Director, US Medical Affairs, PDAC

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity

The Director, US Medical Affairs - PDAC will support the development and execution of the US Medical Affairs strategy and tactical plan for pancreatic ductal adenocarcinoma (PDAC). The role will serve as a US medical and scientific partner for cross-functional teams and help translate the evolving PDAC treatment landscape, external expert perspectives, and field insights into focused medical priorities and activities.

The Director will contribute to launch readiness and post-approval medical activities, including scientific engagement, evidence generation, medical communications, internal education, and patient-focused initiatives. This individual will work closely with US Field Medical, Clinical Development and Operations, Medical Information, Medical Communications, HEOR/RWE, Biomarker and Companion Diagnostics, Commercial, Market Access, Regulatory, Safety, Legal, and Compliance.

The ideal candidate is scientifically rigorous, collaborative, proactive, and comfortable operating in a fast-paced environment. The individual should be able to synthesize complex evidence, develop clear scientific narratives, and execute medical tactics that address meaningful needs in PDAC care.

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Contributes to the development and execution of the US Medical Affairs strategy and annual medical plan for PDAC, including launch readiness, launch execution, and lifecycle planning.

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Translates US-specific evidence gaps, treatment patterns, stakeholder needs, and field insights into clear medical objectives and executable tactics.

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Leads or supports scientific engagement with US external experts through advisory boards, investigator interactions, congress activities, and peer-to-peer scientific exchange.

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Partners with US Field Medical to develop scientific priorities, insight-generation plans, training, and resources that support high-quality scientific exchange.

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Synthesizes insights from external experts, field teams, advisory boards, and other medical activities and communicate implications to internal stakeholders.

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Serves as the PDAC medical content expert on US cross-functional teams and provide scientifically balanced medical input into strategic discussions and decisions.

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Partners with HEOR/RWE, Clinical Development, and Biomarker/Companion Diagnostics teams on evidence-generation priorities addressing US clinical practice, patient identification, biomarker testing, treatment sequencing, safety management, and patient outcomes.

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Coordinates gap assessments and contribute to publication, congress, medical communications, and evidence-generation plans aligned with the US medical strategy.

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Supports the development and review of scientific materials, medical education content, medical information response documents, abstracts, manuscripts, and data-disclosure materials.

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Provides medical leadership for US congress planning, scientific symposia, advisory boards, and other medical activities, ensuring consistency, scientific accuracy, and compliance.

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Partners with Patient Advocacy and Grants teams to incorporate the patient and caregiver perspective and help identify appropriate independent medical education priorities.

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Collaborates with Safety and Clinical teams to support education and scientific exchange related to adverse-event recognition and management in PDAC.

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Ensures all activities are conducted in accordance with applicable legal, regulatory, and compliance requirements.

Required Skills, Experience and Education

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Advanced clinical or scientific degree such as PharmD, PhD, MD, DO, or equivalent.

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10+ years of relevant experience in Medical Affairs within biotechnology or the pharmaceutical industry and/or prior clinical oncology practice.

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Strong scientific background in oncology, with meaningful experience in gastrointestinal cancers and a strong preference for direct PDAC experience.

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Demonstrated ability to analyze, synthesize, and communicate complex clinical and scientific information to internal and external audiences.

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Hands-on experience across core Medical Affairs activities, such as medical strategy, field medical partnership, medical communications, medical information, evidence generation, publications, congress planning, advisory boards, and internal training.

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Experience working effectively with cross-functional partners, including Clinical Development, HEOR/RWE, Biomarkers/Diagnostics, Commercial, Market Access, Regulatory, Safety, Legal, and Compliance.

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Excellent written, verbal, and presentation skills, with the ability to communicate a clear scientific point of view while maintaining appropriate medical balance.

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Ability to manage multiple priorities and stakeholders in a dynamic, evolving environment.

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Ability to travel for internal meetings, external expert engagements, and medical congresses, as required.

Preferred Skills

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Established relationships with US PDAC experts, investigators, advocacy organizations, and multidisciplinary care stakeholders.

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Experience supporting oncology product launch readiness, launch execution, or post-launch medical strategy in the United States.

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Experience in precision oncology, RAS biology, biomarker testing, companion diagnostics, or targeted therapy development.

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Understanding of the US PDAC care pathway, including community and academic treatment settings, patient referral patterns, molecular testing, treatment sequencing, and key evidence gaps.

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Experience supporting clinical-trial strategy or execution, including protocol review, site and investigator engagement, enrollment support, and interpretation of clinical data.

#LI-VN1 #LI-Remote

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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Base Pay Salary Range

$201,000 — $251,000 USD

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