Common Supplement Interactions
Browse 20 researched interaction pairs. Click any to learn more about severity, mechanism, and timing.
Vitamin D3 enhances calcium absorption. These are commonly taken together and considered a beneficial pairing.
Vitamin C significantly enhances non-heme iron absorption. Take together for maximum benefit.
Calcium can significantly reduce iron absorption. Take these supplements at least 2 hours apart.
Both increase serotonin levels. Combined use may lead to serotonin syndrome. Do not combine without medical supervision.
High-dose zinc supplementation can deplete copper levels over time. If taking zinc long-term, consider a zinc:copper ratio of 15:1.
High doses of calcium can reduce magnesium absorption. Best to take at different times of day for optimal absorption.
K2 and D3 work synergistically for bone health. D3 increases calcium absorption while K2 directs it to bones.
Vitamin E helps prevent oxidation of omega-3 fatty acids. Many fish oil supplements already include vitamin E.
Piperine increases curcumin absorption by up to 2000%. These are commonly combined for maximum effectiveness.
B12 and folate work together in methylation processes. Supplementing one without the other can mask deficiency symptoms.
High doses of calcium may reduce zinc absorption. Space these apart by at least 2 hours.
EGCG in green tea can inhibit non-heme iron absorption. Avoid taking iron supplements with green tea.
Magnesium is required for vitamin D metabolism. Adequate magnesium helps activate vitamin D in the body.
Both support sleep quality through complementary mechanisms. Magnesium promotes muscle relaxation while melatonin regulates circadian rhythm.
Both are adaptogenic herbs that help manage stress. They can be combined but start with lower doses as effects may be additive.
Prebiotics serve as food for probiotic bacteria. This combination (synbiotics) enhances probiotic effectiveness.
CoQ10 is fat-soluble and absorbs better with omega-3 fats. Both support cardiovascular health.
Take calcium and magnesium at different times for better absorption. Both compete for the same transport pathways.
High doses of vitamin C may reduce B12 absorption. Space apart or take B12 in the morning and vitamin C later.
L-Theanine smooths out caffeine's stimulating effects, reducing jitters while maintaining focus. A classic nootropic pairing.
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